Tomás Gamasa, MaríaMato Gómez, MauroFernández González, XuliánD'Avino, CinziaMascareñas Cid, José Luis2024-12-132024-12-132024-08-12Mato, M., Fernández-González, X., D'Avino, C., Tomás-Gamasa, M., Mascareñas, J. L. (2024). Bioorthogonal Synthetic Chemistry Enabled by Visible-Light Photocatalysis. “Angew. Chem. Int. Ed.”, 63(47). https://doi.org/10.1002/anie.2024135061433-7851https://hdl.handle.net/10347/38144The field of bioorthogonal chemistry has revolutionized our ability to interrogate and manipulate biological systems at the molecular level. However, the range of chemical reactions that can operate efficiently in biological environments without interfering with the native cellular machinery, remains limited. In this context, the rapidly growing area of photocatalysis offers a promising avenue for developing new type of bioorthogonal tools. The inherent mildness, tunability, chemoselectivity, and external controllability of photocatalytic transformations make them particularly well-suited for applications in biological and living systems. This minireview summarizes recent advances in bioorthogonal photocatalytic technologies, with a particular focus on their potential to enable the selective generation of designed products within biologically relevant or living settings.eng© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbHAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Bioorthogonal chemistryPhotocatalysisPhotoredoxIn vivo synthesisBiomolecule modification2306 Química orgánicajournal article10.1002/anie.2024135061521-3773open access