Losada Castro, PabloGoicoechea Crespo, LauraMascareñas Cid, José LuisGulías Costa, Moisés2024-02-162024-02-162023ACS Catalalysis. 2023, 13, 21, 13994–13999http://hdl.handle.net/10347/32850This article describes the discovery and development of a palladium-catalyzed asymmetric C–H olefination of 2-hydroxybiaryls. The strategy allows a direct assembly of optically active, axially chiral 2-substituted-2′-hydroxybiaryls from readily available precursors and demonstrates that the native hydroxy unit of the substrates can work as an efficient directing group for the C–H activation. This represents a substantial advantage over other approaches that require the preinstallation of metal coordinating units. The simplicity of the approach and versatility of the products allow a practical and efficient synthesis of a broad variety of optically active binaphthyl derivatives.eng© 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0. Open AccessAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/C−H activationCatalysisPalladiumEnantioselectiveAtroposelectivePhenolNaphtholAtropoisomersjournal article10.1021/acscatal.3c038672155-5435open access