Mora Fuentes, Juan PedroVillar Castro, DanielBarbosa de Bessa, J. FranciscoAranda Ruiz, DanielHampel, FrankPérez Meirás, María DoloresPérez Ojeda, M. EugeniaPeña Gil, DiegoHirsch, Andreas2026-04-172026-04-172026-02-15Mora-Fuentes, J. P., Villar-Castro, D., Barbosa-de-Bessa, J. F., Aranda, D., Hampel, F., Pérez, D., Pérez-Ojeda, M.E., Peña, D., & Hirsch, A. (2026) Tuning the Twist by Molecular Design: A New Strategy for Hexabenzocoronene-Containing Helical Twistacene. Chemistry – A European Journal: e03509, 1-9. https://doi.org/10.1002/chem.2025035091521-37650947-6539https://hdl.handle.net/10347/46773In this work, we present an efficient synthetic methodology that allows precise and selective control on the C–C bonds during the Scholl reaction. The first ever described hexabenzocoronene (HBC)-containing helical twistacene NG2 has been obtained with very high yield and practically no need for purification, starting from a helical-twisted hexacene NG1. X-ray analysis reveals an end-to-end twist angle, from approximately 145° in NG1 to 132° in NG2. This approach has provided access to nanographenes (NGs) with improved properties compared to their planar analogues, in particular, enhanced solubility and high stability. In addition, they exhibit interesting redox properties, which, together with their high molar absorbance and optimal energy levels, highlight their potential as new organic semiconductor materials for emerging photovoltaic and electronic technologies.eng© 2026 The Author(s). Chemistry –A European Journal published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Bottom-up approachNanographenesScholl reactionSolubleTwistacenesInvestigaciónjournal article10.1002/chem.202503509open access