González González, José ManuelVidal Pereira, XandroOrtuño Maqueda, Manuel ÁngelMascareñas Cid, José LuisGulías Costa, Moisés2022-12-302022-12-302022J. Am. Chem. Soc. 2022, 144, 47, 21437–214420002-7863http://hdl.handle.net/10347/29687We report the first examples of the use of a new class of ligands (NOBINAc) for performing asymmetric C–H activations using palladium catalysts. These ligands combine the axial chirality of binaphthyl scaffolds with the bifunctional and bidentate coordination properties of mono-N-protected amino acids (MPAAs), which are well-known to favor Pd-promoted C–H activations via concerted metalation–deprotonation mechanisms. We demonstrate that our new ligands enable substantially higher enantioselectivities than MPAAs in the assembly of 2-benzazepines through formal (5 + 2) cycloadditions between homobenzyltriflamides or o-methylbenzyltriflamides and alleneseng© 2022 The Authors. Published by American Chemical Society. This work is under a CC Attribution 4.0 International (CC BY 4.0)Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/AllenesAnnulationsChemical structureLigandsStereoselectivityjournal article10.1021/jacs.2c094791520-5126restricted access