González-Vera, Juan A.Bouzada Reboredo, DavidBouclier, CélineVázquez Sentís, Marco EugenioMorris, May C.2018-07-132018-07-132017González-Vera, J., Bouzada, D., Bouclier, C., Eugenio Vázquez, M., & Morris, M. (2017). Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity. Chemical Communications, 53(45), 6109-6112. doi: 10.1039/c6cc09948c1359-7345http://hdl.handle.net/10347/17023We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb3+] complex incorporated into a CDK4 substrate peptide by a unique tryptophan residue in an adjacent phosphoaminoacid binding moietyeng© The Royal Society of Chemistry 2017journal article10.1039/C6CC09948C1364-548Xopen access