Suárez Lustres, AlejandroMartínez Yáñez, NuriaVelasco Rubio, ÁlvaroVarela Carrete, Jesús ÁngelSaá Rodríguez, Carlos2023-03-172023-03-172023Suárez-Lustres, A., Martínez-Yáñez, N., Velasco-Rubio, A., Varela, J. A., Saá, C. (2023). Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. Org. Lett., 25, 5, 794-7991523-7060http://hdl.handle.net/10347/30335The first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed. The rollover annulation implies a twofold C–H activation of aryl and heteroaryl Csp2–H bonds (C–H/C–H) of 1-benzylpyrazoles (five-atom partners) and alkynes to give the [5 + 2] annulated compounds.eng© 2023 American Chemical Society. This is an open access article under the CC Attribution 4.0 International (CC BY 4.0) license (http://creativecommons.org/licenses/by/4.0/)Annulations2-BenzazepinesCyclizationPalladium catalystjournal article10.1021/acs.orglett.2c043001523-7052open access