Mauricio Iglesias, Miguel2016-12-202016-12-202016Mauricio-Iglesias, M. (2016). Optimal experimental design in the evaluation of food packaging compliance with safety regulations. IFAC-PapersOnLine, vol. 49, no. 7, p. 1133-1138 [DOI 10.1016/j.ifacol.2016.07.355]2405-8963http://hdl.handle.net/10347/1503211th IFAC Symposium on Dynamics and Control of Process SystemsIncluding Biosystems DYCOPS-CAB 2016 — Trondheim, Norway, 6—8 June 2016The determination of diffusivity of compounds that can be transferred from packaging into food products is a keystone to ensure consumer’s safety. However, no clear guidelines exist as how the diffusion experiment should be designed in order to maximise the accuracy of the estimated parameter. With the perspective of optimal experimental design, a methodology to estimate the diffusivity of a migrating compound in a polymer is presented, both for global methods (that measure the overall concentration) and local methods (that measure the profile of concentration along the polymer thickness). To demonstrate the methodology, real experimental data (transfer of Uvitex OB from linear low-density polyethylene) are used, and the OED based methodology is benchmarked against other heuristics. It is seen that, although the OED methodology outperforms the rest of methodologies when good initial guesses are available, its performance becomes deteriorated when gross over- or underestimations of the true value are madeeng© 2016, IFAC (International Federation of Automatic Control)http://creativecommons.org/licenses/by-nc-nd/3.0/es/Optimal Experimental DesignMass TransferParameter EstimationUncertainty AnalysisFood Technologyjournal article10.1016/j.ifacol.2016.07.355open access