Torres López, ManuelPérez-Sayáns García, MarioChamorro Petronacci, CintiaBarros Angueira, FranciscoGándara Vila, PilarLorenzo Pouso, AlejandroGarcía García, Abel2026-04-272026-04-272018-12Torres López, M., Pérez Sayáns, M., Chamorro Petronacci, C., Barros Angueira, F., Gándara Vila, P., Lorenzo Pouso, A., & García García, A. (2018). Determination and diagnostic value of CA9 mRNA in peripheral blood of patients with oral leukoplakia. Journal of Enzyme Inhibition and Medicinal Chemistry, 33(1), 951–955. https://doi.org/10.1080/14756366.2018.14661201475-6366https://hdl.handle.net/10347/46981Background: Oral leukoplakia is one of the most common oral premalignant disorder. The classical evaluation through tissue biopsy is not always valid to evaluate the risk of malignization. Material and methods: RT-qPCR was performed on 47 blood samples (21 patients with leukoplakia, 2 with oral squamous cell carcinoma (OSCC), and 24 healthy patients) and on 11 tissue samples (3 leukoplakia, 4 OSCC, and 4 samples of healthy tissue). Results: There are significant differences in expression between the different groups (F = 4.057, p = .006). The Duncan post hoc test shows that the only group that differentiates is the tumour tissue. Using Wilcoxon test, different covariables of patients with leukoplakia were analysed with respect to the group of healthy patients and no significant differences were observed. Conclusions: The diagnostic route through liquid biopsy has not been conclusive in this study, but there are significant differences in the levels analysed in the different tissue samples.eng© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/CA9Oral squamous cell carcinomaLeukoplakiajournal article10.1080/14756366.2018.14661201475-6374open access