López Caneda, Eduardo GuillermoCadaveira Mahía, FernandoCrego Barreiro, Manuel AlbertoGómez Suárez, Ana FátimaCorral Varela, María MontserratParada Iglesias, MaríaCaamaño Isorna, FranciscoRodríguez Holguín, Socorro2018-06-152018-06-152012López-Caneda E; Cadaveira F; Crego A; Gómez-Suárez AF; Corral M; Parada M; Caamaño F; Rodríguez Holguín S (2012). Hiperactivation of right inferior frontal cortex in young binge drinkers during response inhibition: a follow-up study, Addiction, 107, 1796-1808. Doi:10.1111/j.1360-0443.2012.03908.x0965-2140http://hdl.handle.net/10347/16831This is the peer reviewed version of the following article: López-Caneda E; Cadaveira F; Crego A; Gómez-Suárez AF; Corral M; Parada M; Caamaño F; Rodríguez Holguín S (2012). Hiperactivation of right inferior frontal cortex in young binge drinkers during response inhibition: a follow-up study, Addiction, 107, 1796-1808, which has been published in final form at https://doi.org/10.1111/j.1360-0443.2012.03908.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsAims: The objective of this study was to examine brain activity, with particular attention to prefrontal function, during response execution and inhibition in youths who have engaged in binge drinking (BD) for at least 2 years. Design: Event‐related potentials (ERPs) were recorded twice within 3 years, during performance of a Go/NoGo task. Setting: The study was part of a longitudinal study of the neurocognitive effects of BD. Participants: A total of 48 undergraduate students, 25 controls (14 females) and 23 binge drinkers (10 females), with no personal or family history of alcoholism or psychopathological disorders. Measurements: The Go‐P3 and NoGo‐P3 components of the ERPs were examined by principal component analysis and exact low‐resolution tomography analysis (eLORETA). Findings: Binge drinkers showed larger Go‐P3 amplitudes than controls in the first and second evaluations (P = 0.019). They also showed larger NoGo‐P3 amplitude in the second evaluation (P = 0.002). eLORETA analyses in the second evaluation revealed significantly greater activation of the right inferior frontal cortex (rIFC) in binge drinkers than in controls during successful inhibition (P < 0.05). Conclusions: Young binge drinkers appear to show abnormal brain activity as measured by event‐related potentials during response execution and inhibition which may represent a neural antecedent of difficulties in impulse controleng© 2012 John Wiley & Sons, Inc. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsBinge drinkingeLORETAEvent-related potentialsInhibitory controlNoGo-P3Prefrontal cortexConsumo intensivo de alcoholPotenciales evocadosCórtex prefrontaljournal article10.1111/j.1360-0443.2012.03908.x1360-0443open access