Rodrigues Araújo, Ana RitaCorrea Chinea, Juan FranciscoDomínguez Arca, VicenteReis, Rui L.Fernández Megía, EduardoRodrigues Pires, Ricardo Alexandre2022-07-082022-07-082021ACS Appl. Mater. Interfaces 2021, 13, 50, 59673–596821944-8244http://hdl.handle.net/10347/28892The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.1c17823. Synthesis and characterization of dendrimers, studies of interference of dendrimers in the Aβ supramolecular assembly, and cell studiesThe self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, an important strategy to control Aβ cytotoxicity is the development of bioactive synthetic nanotools capable of interacting with the heterogeneous ensemble of Aβ species and remodel them into noncytotoxic forms. Herein, the synthesis of nanosized, functional gallic acid (Ga)-based dendrimers with a precise number of Ga at their surface is described. It is shown that these Ga-terminated dendrimers interact by H-bonding with monomeric/oligomeric Aβ species at their Glu, Ala, and Asp residues, promoting their remodeling into noncytotoxic aggregates in a process controlled by the Ga units. The multivalent presentation of Ga on the dendrimer surface enhances their ability to interact with Aβ, inhibiting the primary and secondary nucleation of Aβ fibrillization and disrupting the Aβ preformed fibrilseng© 2021 American Chemical Society. This work is licenced under a Creative Commons Attribution 4.0 International licence (https://creativecommons.org/licenses/by/4.0/legalcode)Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/DendrimersGallic acidAmyloid-βSupramolecular assemblyAlzheimer’s diseasejournal article10.1021/acsami.1c178231944-8252open access