Lorenzo Pouso, Alejandro IsmaelGallas Torreira, MercedesPérez-Sayáns García, MarioChamorro Petronacci, Cintia MicaelaÁlvarez Calderón, ÓscarTakkouche, BahiSupuran, Claudiu T.García García, Abel2020-10-272020-10-272020Alejandro I. Lorenzo-Pouso, Mercedes Gallas-Torreira, Mario Pérez-Sayáns, Cintia M. Chamorro-Petronacci, Oscar Alvarez-Calderon, Bahi Takkouche, Claudiu T. Supuran & Abel García-García (2020) Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis, Journal of Enzyme Inhibition and Medicinal Chemistry, 35:1, 1258-1266, DOI: 10.1080/14756366.2020.17722501475-6366http://hdl.handle.net/10347/23446Carbonic anhydrase IX (CAIX) is a hypoxia-related protein considered as a predictor for oral squamous cell carcinoma (OSCC) biological behaviour. Nevertheless, this prognostic value is still yet to be validated. We aim to quantify prognostic significance of CAIX overexpression in OSCC by meta-analysis. We performed searches in MEDLINE, EMBASE, SCOPUS, WOS, WHO’S databases, CPCI, and OATD from inception to August 2019. Overall survival (OS), disease-free survival (DFS), locoregional control (LC), and disease-specific survival (DSS) were considered as outcomes of interest. Overall 18 studies were included. CAIX overexpression was associated with worse OS (hazard ratio [HR] = 1.45 95% confidence interval [CI] 1.17–1.80) and DFS (HR = 1.98 95% CI 1.18–3.32). To the contrary, it was neither associated with LC (HR = 1.01 95% CI 0.50–2.02) nor with DSS (HR = 1.35 95% CI 0.78–2.33). Heterogeneity was negligible in all analyses except for DSS. Small studies effect was not significant for OS and DFS. This study shows that immunohistochemical CAIX assessment is a useful OSCC prognostic biomarkereng© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Mouth neoplasmCarbonic anhydraseMeta-analysisPrognosisHypoxiajournal article10.1080/14756366.2020.17722501475-6374open access