Fais, AntonellaCorda, MarcellaEra, BenedettaFadda, M. BenedettaMatos, Maria João Correia Pinto Carvalho deQuezada González, Elías NeftalíSantana Penín, María LourdesPicciau, CarmenPodda, GianniDelogu, Giovanna Lucia2020-10-212020-10-212009Fais, A.; Corda, M.; Era, B.; Fadda, M.B.; Matos, M.J.; Quezada q, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Molecules 2009, 14, 2514-2520.http://hdl.handle.net/10347/23392In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibitioneng© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)http://creativecommons.org/licenses/by/3.0/Tyrosinase inhibitorsResveratrolCoumarinsjournal article10.3390/molecules140725141420-3049open access