Quezada González, Elías NeftalíDelogu, Giovanna LuciaPicciau, CarmenSantana Penín, María LourdesPodda, GianniBorges, FernandaGarcía Morales, VerónicaViña Castelao, María DoloresOrallo Cambeiro, Francisco2020-10-212020-10-212010Quezada, E.; Delogu, G.; Picciau, C.; Santana, L.; Podda, G.; Borges, F.; García-Morales, V.; Viña, D.; Orallo, F. Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins. Molecules 2010, 15, 270-279http://hdl.handle.net/10347/23393A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivativeseng© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)https://creativecommons.org/licenses/by-nc-sa/3.0/ResveratrolCoumarinVasorelaxantPlatelet antiaggregatory activityjournal article10.3390/molecules150102701420-3049open access