Lago Silva, MaríaCid, María MagdalenaQuiñoá Cabana, EmilioFreire Iribarne, Félix Manuel2024-03-072024-03-072023María Lago-Silva, María Magdalena Cid, Emilio Quiñoá, and Félix Freire. P/M Macromolecular Switch Based on Conformational Control Exerted by an Achiral Side Chain within an Axially Chiral Locked Pendant. Journal of the American Chemical Society 2024 146 (1), 752-7590002-7863http://hdl.handle.net/10347/33032Molecular switches, supramolecular chemistry, and polymers can be combined to create stimuli-responsive multichiral materials. Therefore, by acting on the extended/bent conformational composition of an achiral arm, it is possible to create a macromolecular gear, where different supramolecular interactions can be activated/deactivated to control the helical sense of a polymer containing up to five different chiral axial motifs. For this, a chiral allene with a flexible achiral arm was introduced as a pendant in poly(phenylacetylene). Through flexible arm control between extended and bent conformations, it is possible to selectively induce either a P or M helical sense in the polymer, while the relative spatial distribution of the substituents in the allene remains unaltered in two perpendicular planes (configurationally locked). These results show that complex dynamic multichiral materials can be obtained by the polymerization of appropriate monomers that combine chirality, switching properties, and the ability to generate chiral supramolecular assemblies.eng© 2023 The Authors. Published by American Chemical SocietyAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/journal article10.1021/jacs.3c107661520-5126open access