Rodríguez Riego, RafaelRivadulla Cendal, ElenaQuiñoá Cabana, EmilioFreire Iribarne, Félix Manuel2023-06-222023-06-222023Rodríguez, R, Rivadulla-Cendal, E, Quiñoá, E, Freire, F. Diastereomeric multi-chiral pendant groups: Their key role in stimuli-responsive polymeric responses. Chirality. 2023; 35( 3): 172- 177. doi:10.1002/chir.235300899-0042http://hdl.handle.net/10347/30762Chiral information transmission in helical polymers bearing multi-chiral pen-dant groups is usually determined by the absolute configuration of the first chi-ral center. The second chiral residue usually has low-to-null influence in themacromolecular handedness of the polymer, due to its remote position respectto the polyene main chain. Here, we demonstrate how the stimuli responsiveproperties of diastereomeric polymers, obtained by changing the absolute con-figuration of the second chiral center, are different due to the unlike propertiesof diastereoisomerseng© 2023 The Authors. Chirality published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.http://creativecommons.org/licenses/by-nc/4.0/Chiroptical switchesDiastereomersHelical polymersHelical stretchingSolvent polarityjournal article10.1002/chir.235301520-636Xopen access