Vidal Pereira, XandroMascareñas Cid, José LuisGulías Costa, Moisés2021-07-202022-06-242021Org. Lett. 2021, 23, 14, 5323–53281523-7060http://hdl.handle.net/10347/26594Cycloaddition reactions are among the most practical strategies to assemble cyclic products; however, they usually require the presence of reactive functional groups in the reactants. Here, we report a palladium-catalyzed formal (4 + 2) cycloaddition that involves the activation of C(sp3)–H bonds and provides a direct, unconventional entry to tetrahydroquinoline skeletons. The reaction utilizes amidotolyl precursors and allenes as annulation partners, and is catalyzed by Pd(II) precursors in combination with specific N-acetylated amino acid ligands. The reactivity can be extended to ortho-methyl benzylamides, which provide for the assembly of appealing tetrahydro-2-benzazepines in a formal (5 + 2) annulation procesengCopyright © 2021 American Chemical Society. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archivingHydrocarbonsAromatic compoundsAnnulationsAllenesCyclizationAssembly of Tetrahydroquinolines and 2-Benzazepines by Pd-Catalyzed Cycloadditions Involving the Activation of C(sp3)–H Bondsjournal article10.1021/acs.orglett.1c015941523-7052open access