Gómez Pérez, Inmaculada JénniferMariño, CristinaPérez Meirás, María DoloresGuitián Rivera, EnriquePeña Gil, Diego2024-12-112024-12-112024-10-232046-2069https://hdl.handle.net/10347/38102Multicomponent reactions are powerful strategies for synthesizing complex molecules in an efficient manner. In this work, we investigate a novel multicomponent reaction involving arynes, imines, and nitriles, leading to chiral β-aminonitriles. Notably, two new bonds (C–C and C–N) are formed in one step without the use of metal catalysts, showing the great potential of this transformation. We demonstrate that this synthetic methodology is compatible with different arynes and imines, and propose a reasonable reaction mechanism initiated by the nucleophilic addition of the imine to the aryne.eng© 2024 The Author(s). Published by the Royal Society of Chemistry. This article is Open Access. CC BY-NChttp://creativecommons.org/licenses/by-nc/4.0/Beta-aminonitrilesArynesIminesSynthesisMulticomponent reactions2306 Química orgánicajournal article10.1039/D4RA04499Aopen access