Casanova González, NoeliaSeoane Fernández, AndrésMascareñas Cid, José LuisGulías Costa, Moisés2015-02-232017-08-292015-01-07Casanova, N., Seoane, A., Mascareñas, J. L. and Gulías, M. (2015), Rhodium-Catalyzed (5+1) Annulations Between 2-Alkenylphenols and Allenes: A Practical Entry to 2,2-Disubstituted 2H-Chromenes. Angew. Chem. Int. Ed., 54: 2374–2377. doi: 10.1002/anie.2014103501433-7851E-ISSN 1521-3773http://hdl.handle.net/10347/12381NOTICE: This is the peer reviewed version of the following article: Casanova, N., Seoane, A., Mascarelas, J. L., Gulías, M. (2015), Rhodium-Catalyzed (5+1) Annulations Between 2-Alkenylphenols and Allenes: A Practical Entry to 2,2-Disubstituted 2H-Chromenes. Angew. Chem. Int. Ed., 54: 2374-2377 [doi: 10.1002/anie.201410350]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.Readily available alkenylphenols react with allenes under rhodium catalysis to provide valuable 2,2-disubstituted 2H-chromenes. The whole process, which involves the cleavage of one C-H bond of the alkenyl moiety and the participation of the allene as a one-carbon cycloaddition partner, can be considered a simple, versatile, and atom-economical (5+1) heteroannulation. The reaction tolerates a broad range of substituents both in the alkenylphenol and in the allene, and most probably proceeds through a mechanism involving a rhodium-catalyzed C-C coupling followed by two sequential pericyclic processes.eng© WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimAllenesAnnulationsC-H activationReaction mechanismsRhodiumMaterias::Investigación::23 Químicajournal article10.1002/anie.201410350open access