Nieto-Ortega, BelénRodríguez Riego, RafaelMedina, SamaraQuiñoá Cabana, EmilioRiguera Vega, RicardoCasado, JuanFreire Iribarne, Félix ManuelRamírez, Francisco Javier2019-06-172019-06-172018-04-13Nieto-Ortega, B., Rodríguez, R., Medina, S., Quiñoá, E., Riguera, R., & Casado, J. et al. (2018). Sequential Induction of Chirality in Helical Polymers: From the Stereocenter to the Achiral Solvent. The Journal Of Physical Chemistry Letters, 9(9), 2266-2270. doi: 10.1021/acs.jpclett.8b00519http://hdl.handle.net/10347/18883This is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of the Physical Chemistry Letters, Copyright © 2018 American Chemical Society after peer review and technical edityng by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/10.1021/acs.jpclett.8b00519Several steps of chiral induction have been detected in poly(phenylacetylene)s among their different hierarchical levels of chirality by vibrational circular dichroism, namely, (i) from the stereogenic centers to the innermost polyacetylene helical covalent backbone (helixint), (ii) from this to the external helix (helixext) formed by the side phenyl pendants that form a complementary helix or counter-helix, and (iii) from this pendant helix to the helical solvation sphere (helixsolv.), the last one being observed along this work. The pendant to polyene backbone chiral induction determines the helical structure adopted by the polymer and therefore the solvation helix. This helical structure is promoted by two mechanisms: steric effects and hydrogen bonding. An important finding concerns the demonstration by VCD of how an achiral solvent becomes chirally organized owing to the template effect of the covalent polymer helices, an effect that is silent to other structural techniques such as ECD or AFM and that hence significantly broadens the scope of these previous analysesengCopyright © 2018 American Chemical Societyjournal article10.1021/acs.jpclett.8b005191948-7185open access