Lojo Seoane, CristinaFacal Mayo, DavidGuàrdia-Olmos, JoanPereiro Rozas, Arturo X.Campos Magdaleno, MaríaMallo López, Sabela CarmeJuncos Rabadán, Onésimo2026-04-102026-04-102019-09-24International Psychogeriatrics Volume 32, Issue 4, April 2020, Pages 515-524https://hdl.handle.net/10347/46651Objective To study the influence of cognitive reserve (CR) on cognitive performance of individuals with subjective cognitive complaints (SCCs) within a period of 36 months. Design We used a general linear model repeated measures procedure to analyze the differences in performance between three assessments. We used a longitudinal structural equation modeling to analyze the relationship between CR and cognitive performance at baseline and at two follow-up assessments. Setting Participants with SCCs were recruited and assessed in primary care health centers. Participants A total of 212 participants older than 50 years with SCCs. Measurements Cognitive reserve data were collected with an ad hoc questionnaire administered to the subjects in an interview. General cognitive performance (GCP), episodic memory (EM), and working memory (WM) have been evaluated. The Mini-Mental State Examination and the total score of Spanish version of the Cambridge Cognitive Examination evaluated the GCP. Episodic memory was assessed with the Spanish version of the California Verbal Learning. Working memory was evaluated by the counting span task and the listening span task. Results The satisfactory fit of the proposed model confirmed the direct effects of CR on WM and GCP at baseline, as well as indirect effects on EM and WM at first and second follow-up. Indirect effects of CR on other cognitive constructs via WM were observed over time. Conclusion The proposed model is useful for measuring the influence of CR on cognitive performance over time. Cognitive response acquired throughout life may influence cognitive performance in old age and prevent cognitive deterioration, thus increasing processing resources via WM.eng© International Psychogeriatric Association 2019Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Episodic memoryPreventionCognitive impairmentEducationLifestyleAgingjournal article10.1017/S10416102190012481041-6102open access