Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor

Learte Aymamí, SorayaRodríguez Villar, JéssicaVázquez Sentís, Marco EugenioMascareñas Cid, José Luis2020-07-242021-04-012020S. Learte-Aymamí, J. Rodríguez, M. E. Vázquez, J. L. Mascareñas, Chem. Eur. J. 2020 , 26 , 8875.0947-6539http://hdl.handle.net/10347/23208The nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped with two bipyridine ligands (HkBpy2). These peptides reversibly assemble in the presence of NiII ions at selected DNA sequences of 13 base pairseng© 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsChemical biologyDNA bindingMolecular recognitionPeptidesSupramolecular chemistryAssembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptorjournal article10.1002/chem.2020012771521-3765open access