Booth, RichardInsua López, IgnacioBhak, GhibomMontenegro García, Javier2018-10-292019-10-252018Booth, R., Insua, I., Bhak, G., & Montenegro, J. (2018). Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles. Organic & Biomolecular Chemistry. doi: 10.1039/c8ob02243g1477-0520http://hdl.handle.net/10347/17628Linear peptide amphiphiles are excellent biocompatible scaffolds for the hierarchical self-assembly of one dimensional nanostructures in aqueous media. However, their structural exploration and screening of self-assembling properties is often limited by time-consuming synthesis and purification steps. We here describe the application of the oxime bond as a powerful synthetic tool towards the conjugation of peptide heads bearing a hydroxylamine group with hydrophobic aldehyde tails. This methodology allowed the quick prepraration of a small library of oxime-connected peptide amphiphiles, whose supramolecular screening revealed nano-to-micro fibrillation with dependency on their chemical structure. These results demonstrate the simplicity and the synthetic potential of the oxime conjugation for the preparation of peptide amphiphiles with improved self-assembling capabilitieseng© 2018 Royal Society of Chemistryjournal article10.1039/C8OB02243G1477-0539open access