Rodríguez Osorio, CarlosVences Lorenzo, AnaSuleiman Salameh Abushattal, Saqr2021-06-232021-06-232021http://hdl.handle.net/10347/26498The two subspecies of Photobacterium damselae, namely subsp. damselae and subsp. piscicida, are pathogenic for diverse fish species of financial importance in marine aquaculture. In the present thesis we have characterized the variable genome in these two subspecies, which proved to be highly diverse. We have demonstrated that horizontal gene transfer has played a major role in the acquisition of the ability to metabolize sucrose, and in antimicrobial resistance in the subspecies damselae. Notably, this study has unveiled the existence of a novel, highly unstable virulence plasmid, encoding a Type III secretion system (T3SS) that is highly prevalent in the subspecies piscicida, and which constitutes a new virulence factor in this pathogen.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Photobacterium damselaeplasmidantimicrobial resistancevirulenceaquaculturebacteriaT3SSsucroseMaterias::Investigación::24 Ciencias de la vida::2415 Biología molecular::241501 Biología molecular de microorganismosdoctoral thesisopen access