Pérez Blanco, LucíaFelpete López, AlbaNieto Vieites, AnaLojo Seoane, CristinaCampos Magdaleno, MaríaFernández Feijoo, FátimaJuncos Rabadán, OnésimoPereiro Rozas, Arturo X.2026-01-222026-01-222024-02-02Pérez-Blanco L, Felpete-López A, Nieto-Vieites A, Lojo-Seoane C, Campos-Magdaleno M, Fernández-Feijoo F, Juncos-Rabadán O and Pereiro AX (2024) Predicting progression of cognitive decline to dementia using dyadic patterns of subjective reporting: evidence from the CompAS longitudinal study. Front. Aging Neurosci. 16:1319743. doi: 10.3389/fnagi.2024.13197431663-4365https://hdl.handle.net/10347/45359Objective: To analyze the validity of self and informant reports, depressive symptomatology, and some sociodemographic variables to predict the risk of cognitive decline at different follow-up times. Methods: A total of 337 participants over 50 years of age included in the CompAS and classified as Cognitively Unimpaired (CU), Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) groups were assessed at baseline and three follow-ups. A short version of the QAM was administered to assess the severity of subjective cognitive complaints (SCCs), and the GDS-15 was used to evaluate the depressive symptoms. At each follow-up assessment, participants were reclassified according to the stability, regression or progression of their conditions. Logistic regression analysis was used to predict which CU, SCD and MCI participants would remain stable, regress or progress at a 3rd follow-up by using self- and informant-reported complaints, depressive symptomatology, age and education at baseline and 2nd follow-ups as the predictive variables. Results: Overall, self-reported complaints predicted progression between the asymptomatic and presymptomatic stages. As the objective deterioration increased, i.e., when SCD progressed to MCI or dementia, the SCCs reported by informants proved the best predictors of progression. Depressive symptomatology was also a predictor of progression from CU to SCD and from SCD to MCI. Conclusion: A late increase in self-reported complaints make valid estimates to predict subjective decline at asymptomatic stages. However, an early increase in complaints reported by informants was more accurate in predicting objective decline from asymptomatic stages. Both, early and late decrease in self- reported complaints successfully predict dementia from prodromic stage. Only late decrease in self-reported complaints predict reversion from prodromic and pre-symptomatic stages.eng© 2024 Pérez-Blanco, Felpete-López, NietoVieites, Lojo-Seoane, Campos-Magdaleno, Fernández-Feijoo, Juncos-Rabadán and Pereiro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/subjective cognitive complaintsself-reportinformant-reportdepressive symptomatologysubjective cognitive declinemild cognitive impairmentdementia6108 Psicología de la vejez6105 Evaluación y diagnóstico en psicologíajournal article10.3389/fnagi.2024.1319743open access