Bongard, EmilyVan der Velden, Alike W.Cook, JohannaSaville, BenBeutels, PhilippeAabenhus, Rune MunckBrugman, CurtChlabicz, SlawomirCoenen, SamuelColliers, AnneliesDavies, MelanieDe Paor, MuireannDe Sutter, AnFrancis, Nick A.Glinz, DominikGodycki-ćwirko, MaciekGoossens, HermannHolmes, JaneIeven, MargaretaDe Jong, MennoLindbaek, MortenLittle, PaulMartinón Torres, FedericoMoragas, AnaPauer, JózsefPfeiferová, MarkétaRadzeviciene-Jurgute, RutaSundvall, Pär-DanielTorres, AntoniTouboul, PiaVarthalis, DionyssiosVerheij, TheoButler, Christopher C.2020-05-082020-05-082018Bongard E, van der Velden AW, Cook J, et al. Antivirals for influenzaLike Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4 E): the ALIC4 E protocol. BMJ Open 2018;8:e021032. doi:10.1136/ bmjopen-2017-0210322044-6055http://hdl.handle.net/10347/22175Effective management of seasonal and pandemic influenza is a high priority internationally. Guidelines in many countries recommend antiviral treatment for older people and individuals with comorbidity at increased risk of complications. However, antivirals are not often prescribed in primary care in Europe, partly because its clinical and cost effectiveness has been insufficiently demonstrated by non-industry funded and pragmatic studieseng© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/https://creativecommons.org/licenses/by-nc/4.0/Pandemic influenzaAntiviralsEuropeALIC4 E protocolInfluenzaRetroviralAntivirals for influenza-like illness? a randomised controlled trial of clinical and cost effectiveness in primary carE (ALIC4 E): the ALIC4 E protocoljournal article10.1136/bmjopen-2017-021032open access