Soto-Otero, RamónMéndez Álvarez, EstefaníaIglesias González, JavierUniversidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía. Departamento de Bioquímica e Bioloxía Molecular2014-09-032014-09-032014-09-03http://hdl.handle.net/10347/11435The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and onset of neurodegenerative disorders such as Parkinson’s disease. The main hallmarks found in post‐mortem studies remark the importance of brain free radicals levels, the alteration in brain metabolic parameters and the presence of xenobiotics like metals for the neurodegenerative processes. Also, any energetic deficit related with the metabolic impairment due to an exposition to toxics or an increase in oxidative stress might be a favorable condition for the onset of Parkinson’s disease. Within this framework, and in order to gain insight in the aetiology of Parkinson’s disease, this Thesis was developed as a bioenergetics study focused to oxidative stress, Parkinson’s disease, and aluminium.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glAlzheimermitocondriaataxia de Friedreichesclerosis lateral amiotróficaconcentraciones de metalesMaterias::Investigación::32 Ciencias médicas::3299 otras especialidades medicas (especificar)doctoral thesisopen access