Fernández Casado, JaimeNelson, RonaldMascareñas Cid, José LuisLópez García, Fernando2016-04-042017-08-292016-01-08Fernández-Casado, J., Nelson, R., Mascareñas, J.L. and López, F. (2016), Synergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamides. Chem. Commun., 52, 2909-2912 [DOI:10.1039/C5CC09533F]1359-7345E-ISSN 1364-548Xhttp://hdl.handle.net/10347/14565NOTICE: This is the peer reviewed version of the following article: Jaime Fernández-Casado, Ronald Nelson, José L. Mascareñas* and Fernando López* (2016), Synergistic Gold and Enamine Catalysis: Intermolecular α-Alkylation of Aldehydes with Allenamides. ChemComm., 52, 2909-2912 [10.1039/C5CC09533F]. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archivingAldehydes can be α-alkylated with allenamides by the combined action of an organocatalyst and a gold complex. The reaction requires the simultaneous generation of an enamine and a gold-activated allenamide. Importantly, by using a chiral amine as organocatalyst it is possible to obtain aldehyde products featuring all-carbon quaternary stereocenter at their α-position, with moderate to good levels of enantioselectivityengAldehydesAllenamidesEnantioselectivityGold complexOrganocatalystMaterias::Investigación::23 Químicajournal article10.1039/C5CC09533Fopen access