Majnooni, Mohammad BagherFakhri, SajadSmeriglio, AntonellaTrombetta, DomenicoCroley, Courtney R.Bhattacharyya, PiyaliSobarzo Sánchez, Eduardo MarceloFarzaei, Mohammad HoseinBishayee, Anupam2020-05-152020-05-152019Majnooni, M.B., Fakhri, S., Smeriglio, A., Trombetta, D., Croley, C.R., Bhattacharyya, P., Sobarzo-Sánchez, E., Farzaei, M.H., Bishayee, A. (2019). Antiangiogenic effects of coumarins against cancer: from chemistry to medicine. Molecules 24(23), 4278. doi: 10.3390/molecules24234278http://hdl.handle.net/10347/22349Angiogenesis, the process of formation and recruitment of new blood vessels from pre-existing vessels, plays an important role in the development of cancer. Therefore, the use of antiangiogenic agents is one of the most critical strategies for the treatment of cancer. In addition, the complexity of cancer pathogenicity raises the need for multi-targeting agents. Coumarins are multi-targeting natural agents belonging to the class of benzopyrones. Coumarins have several biological and pharmacological effects, including antimicrobial, antioxidant, anti-inflammation, anticoagulant, anxiolytic, analgesic, and anticancer properties. Several reports have shown that the anticancer effect of coumarins and their derivatives are mediated through targeting angiogenesis by modulating the functions of vascular endothelial growth factor as well as vascular endothelial growth factor receptor 2, which are involved in cancer pathogenesis. In the present review, we focus on the antiangiogenic effects of coumarins and related structure-activity relationships with particular emphasis on cancereng© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/CoumarinsAntiangiogenicCancerNatural agentsChemistryMedicinejournal article10.3390/molecules242342781420-3049open access