García Outeiral, VeraParte, Cristina de laFidalgo Pérez, Miguel Ángel2025-01-172025-01-172021-01-18Garcia-Outeiral V, de la Parte C, Fidalgo M and Guallar D (2021) The Complexity of TET2 Functions in Pluripotency and Development. Front. Cell Dev. Biol. 8:630754. doi: 10.3389/fcell.2020.630754https://hdl.handle.net/10347/38662Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypeseng© 2021 Garcia-Outeiral, de la Parte, Fidalgo and Guallar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/TET2EpigeneticEpitranscriptomicPluripotencyReprogrammingDevelopment5hmC32 Ciencias médicasjournal article10.3389/fcell.2020.6307542296-634Xopen access