Sobrinho, José Lamartine SoaresSoares, Mônica Felts de La RocaTorres Labandeira, SantiagoAlves, Lariza Darlene SantosNeto, Pedro José Rolim2020-05-042020-05-042011Sobrinho, José Lamartine Soares, Soares, Mônica Felts de La Roca, Labandeira, Juan Jose Torres, Alves, Lariza Darlene Santos, & Rolim Neto, Pedro José. (2011). Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins. "Química Nova", 34(9), 1534-15380100-4042http://hdl.handle.net/10347/21996This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of solid state complexes. These were characterized using XRD, SEM and dissolution test. The data obtained suggest the formation of complexes and indicate that these may provide a promising alternative way of developing solid doses of drug with suitable biopharmaceutical properties.engThis article is licensed under a Creative Commons Attribution Licensehttps://creativecommons.org/licenses/by/4.0/deed.enBenznidazoleChagas diseaseInclusion complex and dissolutionjournal article10.1590/S0100-404220110009000101678-7064open access