Padín Santos, DamiánVarela Carrete, Jesús ÁngelSaá Rodríguez, Carlos2020-10-052021-04-032020Padín, D., Varela, J. A., Saá, C. (2020). Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H insertion. Synthesis of Benzofused Six-Membered Azaheterocycles. Org. Lett., 22, 7, 2621-26251523-7060http://hdl.handle.net/10347/23357NOTICE: This is the peer reviewed version of the following article: Padín, D., Varela, J. A., Saá, C. (2020). Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H insertion. Synthesis of Benzofused Six-Membered Azaheterocycles. Org. Lett., 22, 7, 2621-2625. [doi: 10.1021/acs.orglett.0c00596]. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archivingCp*RuCl-based catalyst enables the expedient access to a variety of benzofused six- membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, < 15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed.engCopyright © 2020 American Chemical Society. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archivingCarbenesCarbene/Alkyne metathesisN-H insertionTandem reactionsRutheniumjournal article10.1021/acs.orglett.0c005961523-7052open access