Fernández Fernández, DavidGulías Costa, MoisésMascareñas Cid, José LuisLópez García, Fernando2017-08-312018-07-122017-07-12David Fernández, Moisés Gulías, José L. Mascareñas, Fernando López (2017), Iridium (I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters, Angew. Chem. Int. Ed., 56, 9541-9545 [doi: 10.1002/anie.201705105]http://hdl.handle.net/10347/15752This is the peer reviewed version of the following article: David Fernández, Moisés Gulías, José L. Mascareñas, Fernando López (2017), Iridium (I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters, Angew. Chem. Int. Ed., 56, 9541-9545 [doi: 10.1002/anie.201705105]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archivingA catalytic, versatile and atom-economical C−H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a cationic IrI–bisphosphine catalyst, which promotes a carboxamide-assisted activation of an olefinic C(sp2)−H bond followed by exo-cyclization to a tethered 1,1-disubstituted alkene. The extension of the method to aromatic and heteroaromatic C−H bonds, as well as developments on an enantioselective variant, are also describedeng© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimC−H activationAsymmetric catalysisHydroalkenylationHydroarylationIridiumMaterias::Investigación::23 Química::2302 Bioquímicajournal article10.1002/anie.2017051051521-3773open access