Núñez Martínez, ManuelFernández Míguez, ManuelQuiñoá Cabana, EmilioFreire Iribarne, Félix Manuel2024-10-022024-10-022024M. Núñez-Martínez, M. Fernández-Míguez, E. Quiñoá, F. Freire, Angew. Chem. Int. Ed. 2024, 63, e202403313. https://doi.org/10.1002/anie.202403313http://hdl.handle.net/10347/34993Nanostructuration of dynamic helical polymers such as poly(phenylacetylene)s (PPAs) depends on the secondary structure adopted by the polymer and the functional group used to connect the chiral pendant to the PPA backbone. Thus, while PPAs with dynamic and flexible scaffolds (para- and meta-substituted, ω1<165°) generate by nanoprecipitation low polydisperse nanospheres with controllable size at different acetone/water mixtures, those with a quasi-static behavior and the presence of an extended, almost planar structure (ortho-substituted, ω1>165°), aggregate into a mixture of spherical and oval nanostructures whose size is not controlled. Photostability studies show that poly(phenylacetylene) particles are more stable to light irradiation than when dissolved macromolecularly. Moreover, the photostability of the particle depends on the secondary structure of the PPA and its screw sense excess. This fact, in combination with the encapsulation ability of these polymer particles, allows the creation of light stimuli-responsive nanocarriers, whose cargo can be delivered by light irradiation.eng© 2024 The Author(s). Angewandte Chemie International Edition published by Wiley-VCH GmbHhttp://creativecommons.org/licenses/by-nc/4.0/journal article10.1002/anie.2024033131521-3773open access