Al-Massadi Iglesias, OmarFernø, JohanDiéguez González, CarlosNogueiras Pozo, RubénQuiñones Téllez, María del Mar2020-04-162020-04-162019Al-Massadi, O.; Fernø, J.; Diéguez, C.; Nogueiras, R.; Quiñones, M. Glucagon Control on Food Intake and Energy Balance. Int. J. Mol. Sci. 2019, 20, 3905.http://hdl.handle.net/10347/21473Glucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of appetite and by modulation of lipid metabolism. Moreover, this hormone promotes weight loss by activation of energy expenditure and thermogenesis. In this review, we cover these metabolic actions elicited by glucagon beyond its canonical regulation of glucose metabolism. In addition, we discuss recent developments of therapeutic approaches in the treatment of obesity and diabetes by dual- and tri-agonist molecules based on combinations of glucagon with other peptides. New strategies using these unimolecular polyagonists targeting the glucagon receptor (GCGR), have become successful approaches to evaluate the multifaceted nature of glucagon signaling in energy balance and metabolic syndrome.eng© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)https://creativecommons.org/licenses/by/4.0/GlucagonEnergy balanceFood intakeBody weightEnergy expenditureThermogenesisLipid metabolismObesityjournal article10.3390/ijms201639051422-0067open access