Castelo Baz, PabloRodríguez-Lozano, Francisco JavierGinzo Villamayor, María JoséMiguéns Vila, RamónSeoane Romero, Juan ManuelMartín Cruces, JoséMartín Biedma, Benjamín2024-02-092024-02-092021Castelo-Baz, P., Lozano, F.J.R., Ginzo-Villamayor, M.J. et al. Efficacy of continuous apical negative ultrasonic irrigation (CANUI) in penetration of simulated lateral canals in extracted teeth. Sci Rep 11, 10908 (2021). https://doi.org/10.1038/s41598-021-90430-0http://hdl.handle.net/10347/32653The aim of this study was to evaluate the efficacy of continuous apical negative ultrasonic irrigation into simulated lateral canals and the apical third in straight and curved root canals. Two simulated lateral canals were created 2, 4 and 6 mm from the working length in 120 single-rooted teeth (6 canals/tooth, n = 360 straight, n = 360 curved). The teeth were randomly divided into 3 experimental groups: positive pressure irrigation (PPI) (n = 20); passive ultrasonic irrigation (PUI) (n = 20); continuous apical negative ultrasonic irrigation (CANUI) (n = 20). 20% Chinese ink was added to a 5% sodium hypochlorite solution and delivered into the root canals. The results showed a significantly higher (P < 0.05) penetration of irrigant into the lateral canals and up to working length in the CANUI group for straight and curved roots. CANUI improves penetration into the lateral canals and up to the working length of the cleared teeth in straight and curved roots.engTis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.http://creativecommons.org/licenses/by-nc-sa/4.0/Continuous apical negative ultrasonic irrigation (CANUI)Simulated lateral canals in extracted teethjournal article10.1038/s41598-021-90430-02045-2322open access