Cendón Mariño, BorjaCasanova González, NoeliaComanescu, CezarGarcía Fandiño, RebecaSeoane Fernández, AndrésGulías Costa, MoisésMascareñas Cid, José Luis2017-05-312018-03-272017-03-27Cendón, B., Casanova, N., Comanescu, C., Garcí­a-Fandiño, R., Seoane, A., Gulías, M. & Mascareñas, J.L. 2017, "Palladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes", Organic letters, vol. 19, no. 7, pp. 1674-16771523-7060http://hdl.handle.net/10347/15444This is the peer reviewed version of the following article: Borja Cendón, Noelia Casanova, Cezar Comanescu, Rebeca García-Fandiño, Andrés Seoane, Moisés Gulías* and José L. Mascareñas*, Palladium-Catalyzed Formal (5+2) annulation between ortho-Alkenylanilides and Allenes. Org. Lett. 2017, 19, 1674-1677 [DOI: ]. This article may be used for non commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archiving2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2 and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereoselectivities. Density functional theory (DFT) calculations suggest that the C–H activation of the alkenylanilide involves a classical concerted metalation–deprotonation (CMD) mechanismeng© 2017 American Chemical SocietyPalladium-catalyzedOrtho- alkenylanilidesAllenesMaterias::Investigación::23 Química::2302 Bioquímicajournal article10.1021/acs.orglett.7b004671523-7052open access