Cambeiro Cambeiro, FermínLópez Estévez, SusanaVarela Carrete, Jesús ÁngelSaá Rodríguez, Carlos2020-10-052020-10-052011Cambeiro, F., López, S., Varela, J. A., Saá, C. (2012). Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds. Angew. Chem. Int. Ed., 51, 3, 723-7271433-7851http://hdl.handle.net/10347/23339NOTICE: This is the peer reviewed version of the following article: Cambeiro, F., López, S., Varela, J. A., Saá, C. (2017). Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds. Angew. Chem. Int. Ed. 2012, 51, 3, 723-727. [doi: 10.1002/anie.201107344]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archivingA novel tandem Ru-catalyzed carbene addition to terminal alkynes/insertion of Csp3–H bonds in alkynyl acetals, ethers and amines has been accomplished under mild conditions. This cascade provides an efficient approach to form complex spiro and fused bicyclic structures in 1,5- and 1,6-hydride shift/cyclization sequences from vinylcarbene Ru intermediates.engCopyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archivingAlkynyl derivativesCarbenesCyclizationRutheniumSpiro compoundsjournal article10.1002/anie.2011073441521-3773open access