Castro Tubío, José ManuelOtero Coto, Iago2026-05-202026-05-202026https://hdl.handle.net/10347/47311Transposable elements (TEs) are mobile DNA sequences that comprise over 45% of the human genome. While the majority are currently inactive, some TE families have active copies still mobilising today. When they insert in a new location, a vast variety of genomic alterations can arise which can lead to disease and cancer. Furthermore, TEs incapable of mobilisation can also play a role in genome regulation. Many TEs carry regulatory sequences that can act as enhancers, alternative promoters, and even insulators. In this thesis, we study the effects of these TE-derived regulatory elements in lung cancer taking into account the 3D organisation of the genome. We captured tumour-specific 3D contacts involving TE-derived regulatory elements and found changes in gene expression associated with their spatial proximity.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/transposable elementscancergenome3D241007 Genética humanadoctoral thesisembargoed access