Pazos Chantrero, ElenaGarcía-Algar, ManuelPenas Tallón, CristinaNazarenus, MoritzTorruella, ArnauPazos-Pérez, NicolásGuerrini, LucaVázquez Sentís, Marco EugenioGarcía-Rico, EduardoMascareñas Cid, José LuisÁlvarez-Puebla, Ramón A.2016-12-142017-10-122016-10-12J. Am. Chem. Soc., 2016, 138 (43), pp 14206–142090002-7863http://hdl.handle.net/10347/15020NOTICE: This is the peer reviewed version of the following article: Elena Pazos, Manuel García-Algar, Cristina Penas, Moritz Nazarenus, Arnau Torruella, Nicolas Pazos-Perez, Luca Guerrini, M. Eugenio Vázquez, Eduardo Garcia-Rio*, José L. Macareñas* and Ramon A. Alvarez-Puebla* (2016), SERS Surface Selection Rules for the Proteomic Liquid Biopsy in Real Samples: Efficient Detection of the Oncoprotein cMYC. J. Am. Chem. Soc., 138, 14206-14209 [DOI: 10.1021/jacs.6b08957]. This article may be used for non-commercial purposes in accordance with ACS Publications Terms and Conditions for self-archivingBlood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of human cancers, can be used as a robust proteomic signature for cancer. Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman scattering (SERS) assay for the quantification of c-MYC in real blood samples. The sensing scheme relies on the use of specifically designed hybrid plasmonic materials and their bioderivatization with a selective peptidic receptor modified with a SERS transducer. Peptide/c-MYC recognition events translate into measurable alterations of the SERS spectra associated with a molecular reorientation of the transducer, in agreement with the surface selection rules. The efficiency of the sensor is demonstrated in cellular lines, healthy donors and a cancer patienteng© American Chemical SocietyBlood-based biomarkersDiagnosisCancersSERSMaterias::Investigación::23 Químicajournal article10.1021/jacs.6b089571520-5126open access