Blanco Fernández, GuillermoBlanco Fernandez, BárbaraFernández Ferreiro, AnxoOtero Espinar, Francisco Javier2023-05-262023-05-262023Advances in Colloid and Interface Science 313 (2023) 102867http://hdl.handle.net/10347/30607Liquid crystals (LCs) possess unique physicochemical properties, translatable into a wide range of applications. To date, lipidic lyotropic LCs (LLCs) have been extensively explored in drug delivery and imaging owing to the capability to encapsulate and release payloads with different characteristics. The current landscape of lipidic LLCs in biomedical applications is provided in this review. Initially, the main properties, types, methods of fabrication and applications of LCs are showcased. Then, a comprehensive discussion of the main biomedical applications of lipidic LLCs accordingly to the application (drug and biomacromolecule delivery, tissue engineering and molecular imaging) and route of administration is examined. Further discussion of the main limitations and perspectives of lipidic LLCs in biomedical applications are also providedeng© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/Liquid crystalsDrug deliveryImagingTissue engineeringGlycerol monooleatejournal article10.1016/j.cis.2023.1028670001-8686open access