Paramés Estévez, SantiagoGarcía Acevedo, PelayoRadziunas-Salinas, YagoPiñeiro Redondo, YolandaRivas Rey, JoséFlores Arias, María TeresaPérez Muñuzuri, Alberto2025-10-082025-10-082025-07-11ACS Appl. Nano Mater. 2025, 8, 14505−145182574-0970https://hdl.handle.net/10347/43003Accurate control of energy supplied to a liquid in a controlled environment is essential for automating and optimizing processes. Organs on a chip (OoC) are an emerging technology that allows the design of customized environmental conditions for cells and chemical reactions by creating specific channel shapes while simplifying data acquisition. To thermoregulate these devices and therefore expand their use widely, we integrated iron oxide nanoparticles (IONPs) within the matrix of the chip to heat them by using magnetic hyperthermia. We tested the devices and developed a digital twin that reproduces the experimental OoC-fluid interaction while allowing us to measure parameters that would be inaccessible in a laboratory and get a full picture of the heat transfer at the boundary.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Organ on a chipMicrofluidicsComputer fluid dynamics (CFD)HyperthermiaMagnetic nanoparticlesThermoregulablejournal article10.1021/acsanm.5c01562open access