Blanco Teijeiro, María JoséPardo Pérez, MaríaPiñeiro Ces, AntonioSantiago Varela, María2017-07-042017-07-042017http://hdl.handle.net/10347/15607Malignant uveal melanoma (UM) is the most common primary intraocular tumor in adults. It disseminates primarily through the blood stream and is preferably metastasized in the liver. Even with the successful treatment of UM primary tumors, patients are still at risk for metastases more than 20 years after the initial diagnosis. The aim of this study was to provide new insights on potential biomarkers for UM. We investigated DJ-1 actions in a cell culture, new senescence biomarkers in tissue, and the exosomes as a potential new biomarker in this tumor.spaEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glMelanoma uveal/ Uveal melanomaDJ-1Senescencia/ SenescenceExosomas/ ExosomesMaterias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320109 OftalmologíaMaterias::Investigación::32 Ciencias médicas::3213 Cirugía::321309 Cirugía oculardoctoral thesisopen access