Mosquera Orgueira, AdriánAntelo Rodríguez, BeatrizDíaz Arias, José ÁngelDíaz Varela, Nicolás AntonioBello López, José Luis2020-04-012020-04-012019Mosquera Orgueira, A., Antelo Rodríguez, B., Díaz Arias, J. Á, Díaz Varela, N., & Bello López, J. L. (2019). A three-gene expression signature identifies a cluster of patients with short survival in chronic lymphocytic leukemia. Journal of Oncology, 2019, 1-4. doi:10.1155/2019/94535391687-8450http://hdl.handle.net/10347/21062Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by its heterogeneous clinical evolution. Despite the discovery of the most frequent cytogenomic drivers of disease during the last decade, new efforts are needed in order to improve prognostication. In this study, we used gene expression data of CLL samples in order to discover novel transcriptomic patterns associated with patient survival. We observed that a 3-gene expression signature composed of SCGB2A1, KLF4, and PPP1R14B differentiate a group of circa 5% of cases with short survival. This effect was independent of the main cytogenetic markers of adverse prognosis. Finally, this finding was reproduced in an independent retrospective cohort. We believe that this small gene expression pattern will be useful for CLL prognostication and its association with CLL response to novel drugs should be explored in the future.engCopyright © 2019 Adrián Mosquera Orgueira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedhttps://creativecommons.org/licenses/by/4.0/journal article10.1155/2019/94535391687-8469open access