Alonso Sousa, NereaCaamaño Santos, María OlgaFernández González, FrancoGarcía Mera, XerardoMorales Aguilera, MelvinRodríguez Borges, José E.Clercq, Erik de2021-08-182021-08-182008Alonso, N.; Caamaño, O.; Fernández, F.; García-Mera, X.; Morales, M.; Rodríguez-Borges, J.E.; De Clercq, E. Synthesis and Antiviral Activities of Novel Purinyl- and Pyrimidinylcarbanucleosides Derived from Indan, in Proceedings of the 12th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2008, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-12-012373-906980-20-0http://hdl.handle.net/10347/26850The 12th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural ProductsStarting from (±)-trans- and (±)-cis-3-hydroxymethyl-1-indanol, novel 6-substituted purinylcarbanucleoside derivatives of indan (5, 6, 9, 10, 15 and 17) were synthesized through a key coupling reaction with 6-chloropurine under Mitsunobu conditions. Suzuki–Miyaura reactions of the protected 6-chloropurine derivative with different arylboronic acids afforded the corresponding 6-arylpurinylcarbanucleoside derivatives. Finally, three new 5-halouracilcarbanucleosides (19, 20 and 21) were prepared by reaction of uracilcarbanucleoside 18 with different N-halosuccinimides. All of the new analogues were evaluated for antiviral activity against a wide variety of viruseseng© 2008 The author(s). Published by MDPI, Basel, Switzerland. Open AccessSynthesisIndan carbanucleosidesMitsunobu reactionSuzuki–Miyaura reactionAntiviral activitybook part10.3390/ecsoc-12-01237open access