Miguel Ávila, JoanTomás Gamasa, MaríaMascareñas Cid, José Luis2023-06-152023Miguel-Ávila, J.; Tomás-Gamasa, M.; Mascareñas, J. L. (2023), Metal-promoted synthetic chemistry within living cells. Trends Chem., 5(6): 474–485. doi: 10.1016/j.trechm.2023.04.0012589-7209http://hdl.handle.net/10347/30681The ability to perform 'new-to-nature' chemical reactions within living cells and organisms is transforming the way in which scientists interrogate and/or manipulate biological processes. In recent years, the toolbox of bioorthogonal and cell-compatible reactions has been enriched with the incorporation of transition metal-mediated processes. Whereas the efficiency of these reactions is still low, the breadth and generality of organometallic catalysis promises to significantly impact the field of bioorthogonal chemistry. Particularly attractive is the possibility of using organometallic catalysis for performing bond-forming, synthetically relevant reactions, as this could allow assembly of biorelevant products at specific biological siteseng© 2023 Elsevier Inc. This article may be used for non-commercial purposes in accordance with Elsevier Terms and Conditions for Use of Self-Archived VersionsBioorthogonal chemistryChemical biologyOrganometallic catalysisIntracellular reactionsjournal article10.1016/j.trechm.2023.04.0012589-5974open access