Alfonso Rancaño, María AmparoBayón Lorenzo, JeremíasGegunde Mosquera, SandraAlonso López, EvaAlvariño Romero, RebecaSantás Álvarez, MelisaTesta Fernández, AnaRíos Vázquez, RamónGonzález Juanatey, CarlosBotana López, Luis Miguel2020-04-142020-04-142019Alfonso, A., Bayón, J., Gegunde, S. et al. High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease. Sci Rep 9, 10576 (2019). https://doi.org/10.1038/s41598-019-46988-xhttp://hdl.handle.net/10347/21391Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with infammatory and cardiovascular diseases. While levels of CypA have been extensively studied, less data are available for other Cyps. The purpose of this case-control study was to determine the relationship of Cyps (A, B, C and D) with coronary artery disease (CAD) and eight infammation markers. Serum levels of Cyps, interleukins and metalloproteinases were measured in serum collected from 84 subjects. Participants were divided into two sub-groups based on CAD diagnosis: 40 CAD patients and 44 control volunteers. Serum levels of CypA, CypB and CypC, IL-1β and IL-6 were signifcantly higher in CAD patients. Bivariate correlation analysis revealed a signifcant positive correlation between Cyps and several blood and biochemical parameters. When the ability of Cyps levels for CAD diagnosis was evaluated, higher sensitivity and selectivity values were obtained with CypC (c-statistic 0.891, p<0.001) indicating that it is a good marker of CAD disease, while less conclusive results were obtained with CypA (c-statistic 0.748, p<0.001) and CypB (c-statistic 0.655, p<0.014). In addition, signifcant correlations of traditional CAD risk factors and CypC were observed. In summary, high levels of CypC are a risk factor for CAD and therefore it can be proposed as a new biomarker for this diseaseeng© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/CyclophilinsCoronary artery diseasejournal article10.1038/s41598-019-46988-x2045-2322open access