Cadarso Suárez, Carmen MaríaUña Álvarez, Jacobo deMachado, Luís Filipe MeiraUniversidade de Santiago de Compostela. Facultade de MatemáticasUniversidade de Santiago de Compostela. Departamento de Estatística e Investigación Operativa2014-01-092014-01-092005http://hdl.handle.net/10347/9637This thesis contains some co ntributions for statistical models studying the disease progression. Methods developed in this thesis are largely motivated by the applications to the medical sciences. Disease progression can be well described using multi-state models. These models may be considered as a generalization of the survival process where several (intermediate) events occur successively over time. Multi-state models offer a better understanding of the process of the illness, leading to a better knowledge of the evolution of the disease over time.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glMedicinaModelos estatísticosMarkov, Procesos dedoctoral thesisopen access