Vale González, María del CarmenRaposo García, SandraBotana López, Luis Miguel2026-04-212026-04-212024Vale, Carmen and Raposo-García, Sandra. "5 Toxicological studies with cells". Environmental Toxicology: Non-bacterial Toxins, edited by Luis M. Botana, Berlin, Boston: De Gruyter, 2024, pp. 135-170. https://doi.org/10.1515/9783111014449-0059783111014449https://hdl.handle.net/10347/46861Cell culture provides a model system that provides direct access and evaluation of the effects of chemicals on tissues and constitutes a valuable tool to analyze cell toxicity mechanisms. In vitro model systems, in general, have been used to study the mechanism of action of chemical and to analyze the cellular basis for chemicals-induced toxicity as well as to develop rapid and high throughput screening systems for the evaluation of the toxicity of chemicals, which may complement in vivo toxicity testing or may replace some in vivo models if scientifically validated and accepted by regulatory agencies.engAll Rights ReservedCytotoxicityIn vitroNneuronal culturesImmunocytochemistryMTTWestern blotInvestigaciónbook part10.1515/9783111014449-005open access