Koptelov, MaksimLinck, JanFereidani, Bahar M.Leis Garrote, IsaacVan der Hauwaert, LucasDedieu, IsabelleSommer Schjønberg, MiasHospido Quintana, AlmudenaMauricio Iglesias, Miguel2026-05-252026-05-252026-05-05Cleaner Waste Systems Volume 14, June 2026, 100524https://hdl.handle.net/10347/47388Addressing agri-food waste accumulation via development of sustainable biorefineries is essential for advancing the circular bioeconomy. However, conflicting priorities of stakeholders, from feedstock producers to consumers and policymakers, are significant barriers that disrupt the selection of optimal valorization pathways. This study proposes a methodology to support early-stage biorefinery design by systematically integrating stakeholder preferences. Stakeholder insights are collected through qualitative data analysis (QDA) and translated into explicit design criteria, which are incorporated into the decision-making process. The approach combines multi-criteria decision analysis (MCDA) to identify optimal valorization pathways with life cycle assessment (LCA) to evaluate environmental performance. This enables the simultaneous consideration of economic and environmental objectives while ensuring alignment with stakeholder expectations. The proposed framework serves as a practical roadmap for decision-making in biorefinery design, providing specific recommendations for selecting sustainable and stakeholder-aligned valorization strategies.eng© 2026 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY licenseAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Agricultural waste valorizationBiorefinery designLife Cycle Assessment (LCA)Qualitative researchjournal article10.1016/j.clwas.2026.1005242772-9125open access