Mascareñas Cid, José LuisGulías Costa, MoisésSeoane Fernández, Andrés2016-10-192016-10-192016http://hdl.handle.net/10347/14933One of the main challenges still present within organic synthesis is the ability to achieve complex molecules with high efficiency. In this context metal-catalyzed C-H functionalization processes have gained a lot of attraction due to their ability to increase molecular complexity in few steps and with a minimum generation of waste. These kind of reactions occurs through a metallacyclic intermediate which can be trapped with a huge variety of unsaturated products by a cycloaddition step. This combination of C-H activation and cycloaddition allows to obtain cyclic structures in few steps and high yields. The work realized within my PhD period embraces the field of C-H activation through the development of novel reactivity patterns in Rhodium (III)-catalyzed oxidative annulation reactions. These processes allow to obtain interseting biological and/or biomedic compounds with a high atom and step economy from simple comercial precursors.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glOrganometallic chemistrycatalysisC-H activationannulations230611doctoral thesisopen access